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As time goes by, sodium loss or maybe even treated may cause convulsions, coma, and sometimes even death.

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  • Rarely, patients with Asian ancestry may develop severe skin reactions to carbamazepine Stevens-Johnson syndrome and toxic epidermal necrolysis.
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  • Carbamazepine is excreted by the kidney and eliminated by the liver, and dosages may need to be lowered in patients with liver or kidney dysfunction.

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Does sodium channels of membranes hyperactive nerve cells, reduces the effect of excitatory amino acid neurotransmitter glutamate, aspartate, enhances brake GABAergic processes and the interaction with the central adenosine receptors. Antimanic properties are due to inhibition of metabolism of dopamine and norepinephrine. Anticonvulsant action is manifested in the partial and generalized seizures grand mal. Effective especially in children and adolescents for the relief of symptoms of anxiety and depression, as well as reduce irritability and aggression epilepsy. Prevents attacks of trigeminal neuralgia, reduces the severity of the Carbamazepine generic Online manifestations of alcohol withdrawal including agitation, tremor, gait disturbance and reduces seizure activity. When diabetes insipidus reduces urine Carbamazepine generic Online and thirst.

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Starting anticonvulsant action ranging from several hours to several days sometimes up to 1 month. Antinevralgichesky effect develops after 8 — 72 h, antimanic ; after 7 — 10 days. Application of the substance carbamazepine Epilepsy excluding the petit mal, mania, prophylaxis of manic — depressive disorders, alcohol withdrawal syndrome, trigeminal neuralgia and language — pharyngeal nerves, diabetic neuropathy.

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Interaction Incompatible with MAO inhibitors. It reduces the effects of anticoagulants, anticonvulsants hydantoin derivatives or succinimides, barbiturates, clonazepam, primidone, valproic acid. Phenothiazines, pimozide, thioxanthenes enhance CNS depression; cimetidine, clarithromycin, diltiazem, verapamil, erythromycin, propoxyphene reduce metabolism increased risk of toxicity. Decreases activity of corticosteroids, estrogens and estrogensoderjath oral contraceptives, quinidine, cardiac glycosides induction of metabolism. Against the background of carbonic anhydrase inhibitors increases the risk of osteopenia.

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Do not suddenly stop treatment. Women are recommended folic acid supplementation prior to pregnancy or during her ; in order to prevent excessive bleeding during the last weeks of pregnancy and the newborn possible use of vitamin K.